Anti-PD-L1 兔多克隆抗体-肿瘤标志物,细胞杀伤相关-科普欣生物 Cookbio 抗体|仪器|耗材-武汉科普欣生物科技有限公司

热门搜索： CD3 Actin GFP

Anti-PD-L1 兔多克隆抗体

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￥1900

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货号： K1347112-100

预测分子量： 33 kDa

观测分子量： 40-55 kDa

别名： CD274, B7-H, B7H1, PDL-1, PDCD1L1, PDCD1LG1, PDL1, CD274 molecule, Programmed cell death 1 ligand 1

应用 | 种属

WB M

规格：

100 μL

产品描述
应用
背景
储存条件
图像

产品信息

蛋白质全称	程序性细胞死亡蛋白1配体1
别名	CD274, B7-H, B7H1, PDL-1, PDCD1L1, PDCD1LG1, PDL1, CD274 molecule, Programmed cell death 1 ligand 1
Uniprot ID	Q9EP73
免疫原	对应于小鼠PD-L1的重组蛋白
抗体亚型	IgG
纯化方式	亲和纯化
预测分子量./观测分子量.	33 kDa / 40-55 kDa

应用

WB 免疫印迹

物种:小鼠

稀释比:1: 500-1: 1000

阳性样品:

背景

Plays a critical role in induction and maintenance of immune tolerance to self.As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response.Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10).Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis.The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival.The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function.

储存条件

储存条件：储存条件在：-20℃下储存一年, 避免反复冻融.

储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

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