Anti-Phospho-p53(S392) 兔多克隆抗体-修饰抗体,原癌/抑癌基因蛋白-科普欣生物 Cookbio 抗体|仪器|耗材|试剂-武汉科普欣生物科技有限公司

Anti-Phospho-p53(S392) 兔多克隆抗体

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￥1900

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货号： K1342183-100

预测分子量： 43 kDa

观测分子量： 53 kDa

别名： Antigen NY CO 13, Cellular tumor antigen p53, FLJ92943, LFS1, P53, Phospho-P53 (Ser15), Phosphoprotein p53, TP53, TRP53, tumor protein p53, Tumor suppressor p53, P-P53

应用 | 种属

WB H,M,R

规格：

100 μL 50 μL

产品描述
应用
背景
储存条件
图像

产品信息

蛋白质全称	细胞肿瘤抗原p53
别名	Antigen NY CO 13, Cellular tumor antigen p53, FLJ92943, LFS1, P53, Phospho-P53 (Ser15), Phosphoprotein p53, TP53, TRP53, tumor protein p53, Tumor suppressor p53, P-P53
Uniprot ID	P04637
免疫原	KLH偶联的人p53(S392)合成磷酸肽
抗体亚型	IgG
纯化方式	亲和纯化
预测分子量./观测分子量.	43 kDa / 53 kDa

应用

WB 免疫印迹

物种:人, 小鼠, 大鼠

稀释比:1: 500-1: 1000

阳性样品:

背景

The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis . DNA damage induces phosphorylation of p53 at Ser15 and Ser20 and leads to a reduced interaction between p53 and its negative regulator, the oncoprotein MDM2. p53 can be phosphorylated by ATM, ATR, and DNA-PK at Ser15 and Ser37. Phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and activation of p53 in response to DNA damage.

储存条件

储存条件：储存条件在：-20℃下储存一年, 避免反复冻融.

储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

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