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产品信息
| 蛋白质全称 | ALK核相互作用伴侣 |
|---|---|
| 别名 | Nuclear-interacting partner of anaplastic lymphoma kinase, mNIPA, Zinc finger C3HC-type protein 1, Zc3hc1, Nipa, hNIPA |
| Uniprot ID | Q80YV2 |
| 免疫原 | 小鼠NIPA重组蛋白 |
| 抗体亚型 | IgG |
| 纯化方式 | 亲和纯化 |
| 预测分子量./观测分子量. | 55 kDa / 55 kDa |
应用
WB 免疫印迹
物种:人
稀释比:1: 500-1: 1000
阳性样品:
背景
The regulated oscillation of protein expression is an essential mechanism of cell cycle control. The SCF class of E3 ubiquitin ligases is involved in this process by targeting cell cycle regulatory proteins for degradation by the proteasome, with the F-box subunit of the SCF specifically recruiting a given substrate to the SCF core. NIPA (nuclear interaction partner of ALK) is a human F-box-containing protein that defines an SCF-type E3 ligase (SCFNIPA) controlling mitotic entry. Assembly of this SCF complex is regulated by cell-cycle-dependent phosphorylation of NIPA, which restricts substrate ubiquitination activity to interphase.
储存条件
储存条件：储存条件在：-20℃下储存一年, 避免反复冻融.
储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.
图像
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