Anti-RIP3 兔多克隆抗体-凋亡-科普欣生物 Cookbio 抗体|仪器|耗材-武汉科普欣生物科技有限公司

热门搜索： CD3 Actin GFP

Anti-RIP3 兔多克隆抗体

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￥1900

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货号： K1346374-100

预测分子量： 57 kDa

观测分子量： 57 kDa

别名： Receptor interacting protein 3, RIP 3, RIP like protein kinase 3, RIP3, RIPK3, Rip3 , KIAA0864, M RIP, MPRIP, MRIP, p116Rip, Rho interacting protein 3, RHOIP3

应用 | 种属

WB H

规格：

100 μL

产品描述
应用
背景
储存条件
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产品信息

蛋白质全称	受体相互作用丝氨酸/苏氨酸蛋白激酶3
别名	Receptor interacting protein 3, RIP 3, RIP like protein kinase 3, RIP3, RIPK3, Rip3 , KIAA0864, M RIP, MPRIP, MRIP, p116Rip, Rho interacting protein 3, RHOIP3
Uniprot ID	Q9Y572
免疫原	KLH偶联的人RIP3合成磷酸肽
抗体亚型	IgG
纯化方式	亲和纯化
预测分子量./观测分子量.	57 kDa / 57 kDa

应用

WB 免疫印迹

物种:人

稀释比:1: 300-1: 500

阳性样品:

背景

Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death.Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1.Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage.In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.

储存条件

储存条件：储存条件在：-20℃下储存一年, 避免反复冻融.

储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

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