Anti-MLKL 兔多克隆抗体-凋亡-科普欣生物 Cookbio 抗体|仪器|耗材-武汉科普欣生物科技有限公司

热门搜索： CD3 Actin GFP

Anti-MLKL 兔多克隆抗体

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￥1900

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货号： K1347097-100

预测分子量： 54 kDa

观测分子量： 54 kDa

亚细胞定位：细胞质, 细胞膜, 细胞核

别名： hMLKL, Mixed lineage kinase domain like, Mixed lineage kinase domain like protein, Mixed lineage kinase domain-like protein, mixed lineage kinase domain like pseudokinase

应用 | 种属

WB H

IHC/IF H

规格：

100 μL

产品描述
应用
背景
储存条件
图像

产品信息

蛋白质全称	混合谱系激酶结构域样蛋白
别名	hMLKL, Mixed lineage kinase domain like, Mixed lineage kinase domain like protein, Mixed lineage kinase domain-like protein, mixed lineage kinase domain like pseudokinase
Uniprot ID	Q8NB16
免疫原	KLH偶联的人MLKL合成肽
抗体亚型	IgG
纯化方式	亲和纯化
亚细胞定位	细胞质, 细胞膜, 细胞核
预测分子量./观测分子量.	54 kDa / 54 kDa

应用

WB 免疫印迹

物种:人

稀释比:1: 500-1: 1000

阳性样品:

IHC/IF 免疫组织化学/免疫荧光

物种:人

稀释比:1: 500-1: 1000

阳性样品:

背景

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

储存条件

储存条件：储存条件在：-20℃下储存一年, 避免反复冻融.

储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

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