Anti-BBS8 兔多克隆抗体-其它-科普欣生物 Cookbio 抗体|仪器|耗材|试剂-武汉科普欣生物科技有限公司

Anti-BBS8 兔多克隆抗体

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￥1900

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货号： K1345453-100

预测分子量： 58 kDa

观测分子量： 50 kDa

别名： TPR repeat protein 8, TTC8

应用 | 种属

WB H

规格：

100 μL 50 μL

产品描述
应用
背景
储存条件
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产品信息

蛋白质全称	四肽重复蛋白8
别名	TPR repeat protein 8, TTC8
Uniprot ID	Q8VD72
免疫原	KLH偶联的小鼠TTC8合成肽
抗体亚型	IgG
纯化方式	亲和纯化
预测分子量./观测分子量.	58 kDa / 50 kDa

应用

WB 免疫印迹

物种:人

稀释比:1: 1000-1: 2000

阳性样品:

背景

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.

储存条件

储存条件：-20℃下储存一年, 避免反复冻融.

储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

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