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产品信息
| 蛋白质全称 | DNA错配修复蛋白Mlh1 |
|---|---|
| 别名 | MutL protein homolog 1, COCA2, FCC2, hMLH1, HNPCC, HNPCC2, MLH1 |
| Uniprot ID | P40692 |
| 免疫原 | MLH1重组蛋白 |
| 抗体亚型 | IgG2b, κ |
| 克隆号 | 2A11B2 |
| 纯化方式 | 亲和纯化 |
| 预测分子量./观测分子量. | 85 kDa / 85 kDa |
应用
WB 免疫印迹
物种:人
稀释比:1: 500-1: 1000
阳性样品:
背景
MLH1, also named as COCA2, belongs to the DNA mismatch repair mutL/hexB family. It heterodimerizes with PMS2 to form MutL alpha which is a component of the post-replicative DNA mismatch repair system (MMR). MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. MLH1 also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages.
储存条件
储存条件：储存条件在：-20℃下储存一年, 避免反复冻融.
储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.
图像
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