Anti-PHF19 兔多克隆抗体-转录因子-科普欣生物 Cookbio 抗体|仪器|耗材|试剂-武汉科普欣生物科技有限公司

Anti-PHF19 兔多克隆抗体

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￥1900

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货号： K1345084-100

预测分子量： 65 kDa

观测分子量： 72 kDa

别名： hPCL3, MTF2L1, PCL3, PHD finger protein 19, Polycomb like protein 3

应用 | 种属

WB H,M,R

规格：

100 μL 50 μL

产品描述
应用
背景
储存条件
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产品信息

蛋白质全称	PHD指蛋白19
别名	hPCL3, MTF2L1, PCL3, PHD finger protein 19, Polycomb like protein 3
Uniprot ID	Q9CXG9
免疫原	KLH偶联的小鼠PHF19合成肽
抗体亚型	IgG
纯化方式	亲和纯化
预测分子量./观测分子量.	65 kDa / 72 kDa

应用

WB 免疫印迹

物种:人, 小鼠, 大鼠

稀释比:1: 2000-1: 3000

阳性样品:

背景

Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2).

储存条件

储存条件：-20℃下储存一年, 避免反复冻融.

储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

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