Anti-RANKL 小鼠单克隆抗体-骨相关-科普欣生物 Cookbio 抗体|仪器|耗材-武汉科普欣生物科技有限公司

热门搜索： CD3 Actin GFP

Anti-RANKL 小鼠单克隆抗体

咨询

￥1900

加入对比

货号： K2377115-100

预测分子量： 35 kDa

观测分子量： 38-45 kDa

别名： CD254, hRANKL2, ODF, OPGL, OPTB2, Osteoprotegerin ligand, RANKL, sOdf, TNFSF11, TRANCE, Opgl, Rankl, Trance

应用 | 种属

WB H,M,R

规格：

100 μL

产品描述
应用
背景
储存条件
图像

产品信息

蛋白质全称	肿瘤坏死因子配体超家族成员11
别名	CD254, hRANKL2, ODF, OPGL, OPTB2, Osteoprotegerin ligand, RANKL, sOdf, TNFSF11, TRANCE, Opgl, Rankl, Trance
Uniprot ID	O35235
免疫原	KLH偶联的小鼠 RANKL合成肽
抗体亚型	IgG1, κ
克隆号	4B11F11
纯化方式	亲和纯化
预测分子量./观测分子量.	35 kDa / 38-45 kDa

应用

WB 免疫印迹

物种:人, 小鼠, 大鼠

稀释比:1: 1000-1: 2000

阳性样品:

背景

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor.Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca 2+ resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts.During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation.

储存条件

储存条件：储存条件在：-20℃下储存一年, 避免反复冻融.

储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

图像