| 蛋白质全称 | 神经源性Notch同源蛋白1 |
|---|---|
| 别名 | Notch 1, hN1, Translocation-associated notch protein TAN-1, Notch 1 extracellular truncation, NEXT, Notch 1 intracellular domain, NICD, TAN1, 9930111A19Rik, AOVD1, AOS5 |
| Uniprot ID | P46531 |
| 免疫原 | KLH偶联的人Notch1合成肽 |
| 抗体亚型 | IgG |
| 克隆号 | SB542 |
| 纯化方式 | 亲和纯化 |
| 预测分子量./观测分子量. | 273 kDa / 120 kDa |
NOTCH1, also named as TAN1, belongs to the NOTCH family. NOTCH1 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. NOTCH1 affects the implementation of differentiation, proliferation and apoptotic programs.
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