Anti-SH3BP1 兔多克隆抗体-细胞骨架-科普欣生物 Cookbio 抗体|仪器|耗材|试剂-武汉科普欣生物科技有限公司

Anti-SH3BP1 兔多克隆抗体

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￥1900

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货号： K1342744-100

预测分子量： 74 kDa

观测分子量： 85 kDa

别名： 3BP 1, SH3 domain binding protein 1, SH3BP1

应用 | 种属

WB M

规格：

100 μL 50 μL

产品描述
应用
背景
储存条件
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产品信息

蛋白质全称	SH3结合蛋白1
别名	3BP 1, SH3 domain binding protein 1, SH3BP1
Uniprot ID	P55194
免疫原	小鼠SH3BP1重组蛋白
抗体亚型	IgG
纯化方式	亲和纯化
预测分子量./观测分子量.	74 kDa / 85 kDa

应用

WB 免疫印迹

物种:小鼠

稀释比:1: 300-1: 800

阳性样品:

背景

GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form.By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment.

储存条件

储存条件：储存条件在：-20℃下储存一年, 避免反复冻融.

储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

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